Chris' research focusses on the chronic and acute effects of exercise on peripheral and cerebral vascular function across the lifespan. He utilises cutting-edge ultrasound techniques to explore the therapeutic impact of exercise training and other interventions such as heat therapy, water immersion, ischaemic preconditioning and novel pharmaceuticals in order to reduce cardiovascular disease risk in vulnerable populations. Currently, Chris' research addresses four key areas:
- The influence of habitual exercise on healthy vascular ageing
- The independent and combined effects of exercise training and statin therapy in the primary prevention of cardiovascular disease
- The influence of cardiorespiratory fitness and obesity status on peripheral and cerebral vascular function across the lifespan.
- Characterisation of the 'Athletes Artery': From power lifters to ultramarathon runners.
Refereed Academic Journal Articles
Talbot, J.S., Lord, R.N., Wakeham, D.J., Dawkins, T.G., Curry, B.A., Brown, M., Lodge, F.M.,
Pugh, C.J.A. The influence of habitual endurance exercise on carotid artery strain and strain‐rate in young and middle‐aged men.
Experimental Physiology. 105: 1396-1407, 2020
Lord, R.N., Wakeham, D.J.,
Pugh, C.J.A., Simpson, L.L., Talbot, J.S., Lodge, F.M., Curry, B.A., Dawkins, T.G., Shave, R.E., Moore, J.P. The influence of barosensory vessel mechanics on the vascular sympathetic baroreflex: insights into ageing and blood pressure homeostasis.
American J Physiology; Heart & Circulatory Physiology. 319 (2): H370-H376, 2020
Cullen, T., Clarke, N. D., Hill, M., Menzies, C.,
Pugh, C. J. A., Steward, C.J., Thake, C. D. The health benefits of passive heating and exercise: to what extent do the mechanisms overlap.
Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00608. 2020 [In-Press].
Dawkins, T.G., Curry, B.A., Drane, A., Lord, R.N., Richards, C., Brown, M.,
Pugh, C.J.A., Lodge, F.M., Yousef, Z., Stembridge, M., Shave, R.E. Stimulus-specific functional remodeling of the left ventricle in endurance and resistance-trained men.
American J Physiology; Heart & Circulatory Physiology https://doi.org/10.1152/ajpheart.00233.2020 [In Press]
Pugh, J.D.,
Pugh, C.J.A. Neurostimulation, doping, and the spirit of sport.
Neuroethics. https://doi.org/10.1007/s12152-020-09435-7. 2020 [In Press]
Wakeham, D.J., Lord, R.N., Talbot, J.S., Curry, B., Lodge, F., Dawkins, T., Simpson, L.L., Shave, R., Moore, J.P.,
Pugh, C.J.A. Upward resetting of the vascular sympathetic baroreflex in middle-aged male runners.
American J Physiology; Heart & Circulatory Physiology. 317:H181-H189, 2019
Pugh, C.J.A., Stone, K.J., Stöhr, E.J., McDonnell, B.J., Thompson, J.E.S., Talbot, J.S., Wakeham, D.J., Cockcroft, J.R., Shave, R. Carotid artery wall mechanics in young males with high cardiorespiratory fitness.
Experimental Physiology. 103 (9): 1277-1286, 2018
Carter, H.H., Spence, A.L.,
Pugh, C.J.A., Ainslie, P.H., Naylor, L.H., Green, D.J. Differential impact of water immersion on arterial blood flow and shear stress in the carotid and brachial arteries of humans.
Physiological Reports, 5 (10), e13285, 2017
Pugh, J.D.,
Pugh, C.J.A., Savulescu, J. Exercise prescription and the doctor's duty of non-maleficence.
British Journal of Sports Medicine, 51 (21) , 1555-1556, 2017
Black, J.M., Stohr, E.J., Stone, K.,
Pugh, C.J.A., Stembridge, M., Shave, R., Esformes, J.I. The effect of an acute bout of resistance exercise on carotid artery strain and strain rate.
Physiological Reports; 4 (17): e12959, 2016
Pugh C.J.A, Sprung VS, Jones H, Richardson P, Shojaee-Moradie F, Umpleby AM, Green DJ, Cable NT, Trenell MI, Kemp GJ, Cuthbertson DJ. Exercise-induced improvements in liver fat and endothelial function are not sustained 12 months following cessation of exercise supervision in non-alcoholic fatty liver disease (NAFLD).
International Journal of Obesity; 40: 1927-1930, 2016.
Cuthbertson, D.J., Shoajee-Moradie, F., Sprung, V.S., Jones. H.,
Pugh, C.J.A., Richardson, P., Kemp, G.J., Barrett, M., Jackson, N.C., Thomas, E.L., Bell, J.D., Umpleby, A.M. Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease.
Clinical Science; 130: 93-104, 2016.
Pugh, C.J.A., Sprung, V.S., Ono, K., Spence, A.L., Thijssen, D.H.J., Carter, H.H., Green, D.J. The impact of water immersion during exercise on cerebral blood flow. Medicine and Science in Sport and Exercise; 47: 299-306, 2015.
Pugh CJ, Sprung VS, Kemp GJ, Richardson P, Shojaee-Moradie F, Umpleby AM, Green DJ, Cable NT, Jones H, and Cuthbertson DJ. Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease.
American J Physiology; Heart & Circulatory Physiology 307: 1298-1306, 2014.
Green, D.J., Eijsvogels, T., Bouts, Y., Maiorana, A., Naylor, L.H., Scholten, R.,
Pugh, C.J.A., Sprung, V.S., Schreuder, T., Jones, H., Cable, N.T., Hopman, M.T.E., Thijssen, D.H.J. Factors predicting the impact of exercise training on vascular health in humans: A pooled analysis of responders and non-responders.
Journal of Applied Physiology 117: 345-352, 2014.
Thijssen, D.H.J., Atkinson, C.L., Ono, K., Sprung, V.S., Spence, A.L., Pugh, C.J.A., Green, D.J. Sympathetic nervous system activation, arterial shear rate and flow mediated dilation.
Journal of Applied Physiology 116: 1300-1307, 2014.
Carter, H.H., Spence, A.L., Atkinson, C.L.,
Pugh, C.J.A., Cable, N.T., Thijssen, D.H.J., Naylor, L.H., Green, D.J. Distinct impacts of skin blood flow and temperature on cutaneous microvascular adaptation in humans. Medicine and Science in Sport and Exercise; 46: 2113–2121, 2014.
Cuthbertson, D.J. Irwin, A.,
Pugh, C.J.A., Jones. H., Sprung, V.S., Daousi, C., Adam, V.L., Bimson, W.E., Shoajee-Moradie, F., Umpleby, A.M., Wilding, J.P., Kemp, G.J. Ectopic lipid storage in Non-Alcoholic Fatty Liver Disease is not mediated by impaired mitochondrial oxidative phosphorylation in skeletal muscle.
Clinical Science; 127: 655-663, 2014.
Carter, H.H., Spence, A.L.,
Pugh, C.J.A., Ainslie, P.H., Naylor, L.H., Green, D.J. Cardiovascular responses to water immersion in humans: Impact on cerebral perfusion.
American Journal of Physiology Regulatory, Integrative and Comparative Physiology; 306: R636–R640, 2014.
Pugh C.J.A., Cuthbertson, D.J., Sprung, V.S., Kemp, G.J., Richardson, P., Umpleby, A.M., Green, D.J., Cable, N.T., Jones. H. Exercise training improves cutaneous microvascular function in non-alcoholic fatty liver disease.
American Journal of Physiology: Endocrinology & Metabolism, 305, E50-58, 2013.
Carter, H.H., Spence, A.L., Atkinson, C.L.,
Pugh, C.J.A., Naylor, L.H., Green, D.J. Repeated core temperature elevation induces conduit artery adaptation in humans.
European Journal of Applied Physiology; 114(4): 859-65, 2013.
Sprung, V.S., Cuthbertson, D.J., Pugh, C.J.A., Atkinson, G., Aziz, N., Kemp, G.J., Green, D.J., Cable, N.T., Jones H. Nitric-oxide mediated cutaneous microvessel function is impaired in PCOS women and can be improved with exercise training.
The Journal of Physiology, 15; 591, 1475-87, 2013.
Sprung, V.S., Jones. H.,
Pugh, C.J.A., Aziz, N., Kemp, G.J., Green, D.J., Atkinson, G., Cable, N.T., Cuthbertson, D.J. Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition. Clinical Science, 126, 67-74, 2013.
Sprung, V.S., Cuthbertson, D.J., Pugh, C.J.A., Aziz, N., Kemp, G.J., Daousi, C., Atkinson, G., Green, D.J., Cable, N.T., Jones, H. Exercise Training in PCOS Enhances FMD in the Absence of Changes in Fatness.
Medicine and Science in Sport and Exercise, 45(12):2234-42, 2013.
Mills, A., Rosenberg, M., Stratton. G., Carter, H.H., Spence, A.L.,
Pugh, C.J.A., Green, D.J., Naylor, L.H. The effect of exergaming on vascular function in children.
Journal of Pediatrics, 163(3):806-10, 2013
Hopkins, N.D., Cuthbertson, D.J, Kemp, G.J.,
Pugh, C.J.A., Green, D.J., Cable, N.T., Jones, H. Effects of 6 months glucagon-like peptide-1 (GLP-1) receptor agonists treatment on endothelial function in patients type 2 diabetes mellitus.
Diabetes, Obesity and Metabolism, 15(8), 770-773, 2013.
Sprung, V.S., Atkinson, G., Cuthbertson, D.J.,
Pugh, C.J.A., Aziz, N., Green, D.J., Cable, N.T., & Jones, H. Endothelial Function measured using Flow Mediated Dilation in Polycystic Ovarian Syndrome: A meta-analysis.
Clinical Endocrinology (Oxf), 78, 438-446, 2012.
Jones, H., Sprung, V.S.,
Pugh, C.J.A., Daousi, C., Irwin, A., Aziz, N., Adams, V.L., Thomas, E.L., Bell, J.D., Kemp, G.J., & Cuthbertson, D.J. Polycystic Ovary Syndrome with hyperandrogenism is characterised by an increased risk of hepatic steatosis, compared to non-hyperandrogenic PCOS phenotypes and healthy controls, independent of obesity.
Journal of Clinical Endocrinology and Metabolism, 97(10), 3709-16, 2012.
Atkinson, G.,
Pugh, C., & Scott, M. A. Exploring data distribution prior to analysis: Benefits and pitfalls. Int J Sports Med, 31(12), 841-842, 2010.
