Teaching
I teach medical microbiology on the Biomedical Sciences and Health Care Science BSc degree courses as well as on the MSc Biomedical Science degree course.
First Year tutor for the BSc Health Care Sciences Programme
Modules involved with:
Undergraduate
APS4011 & APS4018 - Laboratory Skills and Data Analysis
APS4013 - Infection and Immunity A
APS5027 - Infection and Immunity B
APS5032 - Professional practice and specialism A
APS6017 - Infection Sciences - Specialism B - Module Lead
APS6020 - The Biology & Laboratory Investigation of Disease
APS6022 - Research Project
APS6026 - Research Project
APS6024 - Contemporary Topics in Biomedical Science
Postgraduate
MBS7008 - Medical Microbiology
MBS7021 - Analytical and Diagnostic Techniques
MBS7028 - Recent advances in Biomedical Sciences
MBS7010 - Dissertation
Research
My research interests are on predatory bacteria and their applications in therapeutic models of infectious diseases. Major areas of my studies involve isolation of Myxobacteria from various environmental sources studying their phylogenetic and predatory/killing activities against pathogenic microbes using the cutting-edge omics technology and conventional assays. Further, to investigate the application of these predatory bacteria in infection models such as In vitro, Ex vivo or In vivo models with the aim of translational research is the broader outlook.
More recently I have expanded my research interests into Fusobacterium necrophorum, an under-studied and under-diagnosed pathogen. Using the omics approach to study the virulome and extrapolate the inferences using In-vitro or Ex-vivo models with an aim of investigating the pathogenesis and host pathogen relationships is the focus of this study. I characterise Fusobacterium necrophorum isolates of respiratory and other systemic sources in view of looking for marker genes/proteins which can be used in diagnostic clinical microbiology.
Publications
Chambers, J., Sparks, N., Sydney, N., Livingstone, P.G., Cookson, A.R. and Whitworth, D.E., 2020. Comparative genomics and pan-genomics of the Myxococcaceae, including a description of five novel species: Myxococcus eversor sp. nov., Myxococcus llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogochensis sp. nov., Myxococcus vastator sp. nov., Pyxidicoccus caerfyrddinensis sp. nov. and Pyxidicoccus trucidator sp. nov. Genome Biology and Evolution. 2020 Oct 6:evaa212. doi: 10.1093/gbe/evaa212.
Anbarasu, A., Ramaiah, S. and Livingstone, P., 2020. Vaccine repurposing approach for preventing COVID 19: can MMR vaccines reduce morbidity and mortality?. Human Vaccines & Immunotherapeutics, pp.1-2.
Zwarycz, A.S., Livingstone, P.G. and Whitworth, D.E., 2020. Within-species variation in OMV cargo proteins: the Myxococcus xanthus OMV pan-proteome. Molecular Omics. 2020 Aug 1;16(4):387-397
Livingstone, P.G., Ingleby, O., Girdwood, S., Cookson, A.R., Morphew, R.M. and Whitworth, D.E., 2020. Predatory Organisms with Untapped Biosynthetic Potential: Descriptions of Novel Corallococcus Species C. aberystwythensis sp. nov., C. carmarthensis sp. nov., C. exercitus sp. nov., C. interemptor sp. nov., C. llansteffanensis sp. nov., C. praedator sp. nov., C. sicarius sp. nov., and C. terminator sp. nov. Applied and environmental microbiology, 86(2).
Sutton, D., Livingstone, P.G., Furness, E., Swain, M. and Whitworth, D.E., 2019. Genome-wide identification of myxobacterial predation genes and demonstration of formaldehyde secretion as a potentially predation-resistant trait of Pseudomonas aeruginosa. Frontiers in Microbiology, 10, p.2650.
Sengupta, K., Swain, M.T., Livingstone, P.G., Whitworth, D.E. and Saha, P., 2018. Genome Sequencing and Comparative Transcriptomics Provide a Holistic View of 4-Nitrophenol Degradation and Concurrent Fatty Acid Catabolism by Rhodococcus sp. Strain BUPNP1. Frontiers in microbiology, 9, p.3209.
Livingstone, P.G., Morphew, R. and Whitworth, D.E., 2018. Genome sequencing and pan-genome analysis of 23 Corallococcus spp. strains reveal unexpected diversity, with particular plasticity of predatory gene sets. Frontiers in microbiology, 9, p.3187.
Livingstone, P.G., Morphew, R.M., Cookson, A.R. and Whitworth, D.E., 2018. Genome Analysis, Metabolic Potential, and Predatory Capabilities of Herpetosiphon llansteffanense sp. nov. Appl. Environ. Microbiol., 84(22), pp.e01040-18.
Livingstone, P.G., Millard, A.D., Swain, M.T. and Whitworth, D.E., 2018. Transcriptional changes when Myxococcus xanthus preys on Escherichia coli suggest myxobacterial predators are constitutively toxic but regulate their feeding. Microbial genomics, 4(2).
Livingstone, P.G., Morphew, R.M. and Whitworth, D.E., 2017. Myxobacteria are able to prey broadly upon clinically-relevant pathogens, exhibiting a prey range which cannot be explained by phylogeny. Frontiers in microbiology, 8, p.1593.
Brahmadathan, K.N. and Gladstone, P., 2006. Microbiological diagnosis of streptococcal pharyngitis: lacunae and their implications. Indian journal of medical microbiology, 24(2), p.92.
Jesudason, M.V. and Gladstone, P., 2006. Culture proven cases of tuberculous meningitis: A 5 year retrospective analysis from Vellore. Indian journal of medical microbiology, 24(3), p.237.
Gladstone, P., Varghese, G. and Brahmadathan, K.N., 2005. Dynamics of anti-M antibody response in a mouse model following intranasal infection with group A Streptococcus M-18. Journal of medical microbiology, 54(3), pp.305-308.
Brahmadathan, K.N., Anitha, P. and Gladstone, P., 2005. Increasing erythromycin resistance among group A streptococci causing tonsillitis in a tertiary care hospital in southern India. Clinical microbiology and infection, 11(4), pp.335-337.
Gladstone, P., Rajendran, P. and Brahmadathan, K.N., 2005. Incidence of carbapenem resistant nonfermenting gram negative bacilli from patients with respiratory infections in the intensive care units. Indian journal of medical microbiology, 23(3), p.189.
Jesudason, M.V. and Gladstone, P., 2005. Non tuberculous mycobacteria isolated from clinical specimens at a tertiary care hospital in South India. Indian journal of medical microbiology, 23(3), p.172.
Gladstone, P., Jesudason, M.V. and Sridharan, G., 2003. Invasive properties of South Indian strains of Streptococcus pyogenes in a HEp-2 cell model. Clinical microbiology and infection, 9(10), pp.1031-1034.
Gladstone P, Mathai E, Lalitha MK ., 2001 High prevalence of ESBL producing Klebsiella strains in Nosocomial Respiratory Infections. Natl Med J Ind 2001 Nov-Dec;14(6): 380
Collaborators
Aberystwyth University
Public Health Wales NHS Trust
Christian Medical College & Hospital – Vellore – South India
Vellore Institute of Technology – Vellore – South India
External Links
Registrant with the Health and Care Professions Council (BS49466)
All Wales Biomedical Scientist Trainers Forum
Associate Fellow of the Higher Education Academy
Fellow of the Institute of Biomedical Science
Member of the Royal Society of Biology
Member of the Microbiology Society
Member of the Society for Applied Microbiology
Member of the Welsh Microbiology Association
Member of the Indian Association of Medical Microbiologists
